2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-132117
    Bromo-PEG12-t-butyl ester
    Bromo-PEG12-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG12-t-butyl ester
  • HY-129774
    Phthalimide-PEG4-MPDM-OH
    Phthalimide-PEG4-MPDM-OH is a PROTAC linker, which refers to the PEGs composition. Phthalimide-PEG4-MPDM-OH can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
    Phthalimide-PEG4-MPDM-OH
  • HY-138497
    F-PEG2-S-COOH
    F-PEG2-S-COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    F-PEG2-S-COOH
  • HY-130534
    Tos-PEG2-Boc 1309666-78-1 98.0%
    Tos-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tos-PEG2-Boc
  • HY-140580
    Bis(m-PEG4)-N-OH 2182601-79-0
    Bis(m-PEG4)-N-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bis(m-PEG4)-N-OH
  • HY-140281
    DBCO-C-PEG1 2377004-09-4
    DBCO-C-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-C-PEG1 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-C-PEG1
  • HY-140550
    NH-bis(C2-PEG1-azide) 2100306-81-6
    NH-bis(C2-PEG1-azide) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH-bis(C2-PEG1-azide) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    NH-bis(C2-PEG1-azide)
  • HY-140162
    Hydroxy-PEG4-methylamine 90430-59-4
    Hydroxy-PEG4-methylamine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hydroxy-PEG4-methylamine
  • HY-49453
    Fmoc-Gly-Gly-(D-Phe)-Gly-CH2-O-CH2-Cbz
    Fmoc-Gly-Gly-(D-Phe)-Gly-CH2-O-CH2-Cbz is a PROTAC linker and a maleimide-GGFG peptide linker. Fmoc-Gly-Gly-(D-Phe)-Gly-CH2-O-CH2-Cbz can be used in the synthesis of the Deruxtecan.
    Fmoc-Gly-Gly-(D-Phe)-Gly-CH2-O-CH2-Cbz
  • HY-159575
    COOEt-cyclohexane-C-Ph-pyrimidine-diazabicyclo
    COOEt-cyclohexane-C-Ph-pyrimidine-diazabicyclo is a PROTAC linker. COOEt-cyclohexane-C-Ph-pyrimidine-diazabicyclo can be used in the synthesis of PROTAC SMARCA2/4-degrader-5 (HY-159456).
    COOEt-cyclohexane-C-Ph-pyrimidine-diazabicyclo
  • HY-133395
    Azido-PEG9-azide 1171122-72-7
    Azido-PEG9-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG9-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG9-azide
  • HY-140318
    DBCO-mPEG (MW 2kDa)
    DBCO-mPEG (MW 2kDa) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-mPEG (MW 2kDa) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-mPEG (MW 2kDa)
  • HY-132049
    Benzyl-PEG7-azide 868594-42-7
    Benzyl-PEG7-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Benzyl-PEG7-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Benzyl-PEG7-azide
  • HY-141323
    C2-Bis-phosphoramidic acid diethyl ester 34008-16-7
    C2-Bis-phosphoramidic acid diethyl ester is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    C2-Bis-phosphoramidic acid diethyl ester
  • HY-W096141
    Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite 1391728-01-0
    Propargyl-PEG3-1-o-b-cyanoethyl-NN-diisopropylphosphoramidite is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite
  • HY-140593
    m-PEG3-S-PEG2-OH 2173095-09-3
    m-PEG3-S-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG3-S-PEG2-OH
  • HY-141309
    m-PEG4-(CH2)6-Phosphonic acid 2028281-85-6
    m-PEG4-(CH2)6-Phosphonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG4-(CH2)6-Phosphonic acid
  • HY-140340
    Fmoc-NH-pentanoic acid-NHS-SO3Na
    Fmoc-NH-pentanoic acid-NHS-SO3Na is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-NH-pentanoic acid-NHS-SO3Na
  • HY-132097
    Bromo-PEG4-PFP ester
    Bromo-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG4-PFP ester
  • HY-141186A
    (R)-TCO-OH 39637-78-0
    (R)-TCO-OH is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. (R)-TCO-OH is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
    (R)-TCO-OH
PROTAC Linkers Isoform Comparison

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